Morphologic features (Pathologic findings, Arch Pathol Lab Med 2021)

관리자
2022-08-06
조회수 147


Helicobacter pylori gastritis in a patient who was subsequently diagnosed with autoimmune gastritis. This case features full-thickness inflammation of oxyntic mucosa (A), pyloric metaplasia (B), enterochromaffin-like cell hyperplasia (C), and abundant H pylori (D) (hematoxylin-eosin, original magnifications ×20 [A] and ×400 [B]; chromogranin immunostain, original magnification ×400 [C]; H pylori immunostain, original magnification ×400 [D]).


Combined features of autoimmune gastritis in a background of Helicobacter pylori infection. Body mucosa with oxyntic gland loss (A) shows an absence of gastrin staining (B) along with linear enterochromaffin-like cell hyperplasia (C) and H pylori gastritis (D) (hematoxylin-eosin, original magnification ×40 [A]; gastrin immunostain, original magnification ×40 [B]; chromogranin immunostain, original magnification ×400 [C]; H pylori immunostain, original magnification ×400 [D]). 


Early autoimmune gastritis in a patient after Helicobacter pylori eradication. The biopsy specimen shows full-thickness chronic inflammation of the oxyntic mucosa (A) and pyloric metaplasia of the deep oxyntic glands (B) (hematoxylin-eosin, original magnifications ×20 [A] and ×400 [B]). 


Florid-stage autoimmune gastritis in a follow-up biopsy from a patient who underwent Helicobacter pylori eradication therapy. The biopsy specimen features full-thickness chronic inflammation with oxyntic gland loss (A), a negative gastrin immunostain (B), and linear enterochromaffin-like cell hyperplasia on a chromogranin immunostain (C) (hematoxylin-eosin, original magnification ×100 [A]; gastrin immunostain, original magnification ×100 [B]; chromogranin immunostain, original magnification ×100 [C]). 


A prospectively identified case of Helicobacter pylori and autoimmune gastritis. A, Full-thickness inflammation and loss of oxyntic glands characterize this case of chronic gastritis. B, Origin in oxyntic mucosa is demonstrated by a negative gastrin immunostain. C, A chromogranin immunostain shows linear and nodular ECL cell hyperplasia. D, An immunostain is positive for H pylori (hematoxylin-eosin, original magnification ×80 [A]; gastrin immunostain, original magnification ×84 [B]; chromogranin immunostain, original magnification ×84 [C]; H pylori immunostain, original magnification ×400 [D]). 


<참고자료>

Features That Aid Identification of Autoimmune Gastritis in a Background of Active Helicobacter pylori Infection. 

Arch Pathol Lab Med. 2021 Dec 1;145(12):1536-1543.

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